A potential Cancer Therapy Target

Vogel Group, Department of Cellular and Molecular Medicine


Gives hope for cancer treatment.

Prober regulation of matriptase can rescue the oncogenic potential of matriptase.
  • 10/10 mice that overexpressed matriptase developed dysplasia (tumors).

  • 70% of these were malignant tumors.

  • About 50% of this oncogenic effect can be completly rescued due to simultaneous HAI-1 or HAI-2 overexpression.
  • The matriptase inhibitors HAI-1 and HAI-2 causes regression of already estaplished tumors.

Matriptase is a membrane anchored serine protease, expressed in all types of epithelial cells.

This protease plays a central role in oncogenesis, shown in several studies in transgenic mice, conducted by e.g. List et al., and Sales et al. 

Matriptase is highly oncogenic when not properly regulated.
Evidence for this is provided by overexpression of matriptase controlled by a tissue specific constitutive promotor insuring overexpression solely in the epidermis of mice, illustrating a single-handedly and very potently Matriptase dependent induction of (ras-independent) squamous cell carcinomas  (SCC) with high penetrance.

Vogel Group

Vogel Group is an ambitious cancer research group, that contributes greatly to the literature on epithelial-derived cancer which is the origin of 90% of all types of cancer

Our focus is to explore regulation of Matriptase, a novel and promising target in cancer treatment, in order to fully understand and potentially cure cancer. 
The group is highly cooperation, and the strategy and structure is of highest level, everything we do is controlled and improved continuously, and the atmosphere is remarkable
Master´s Thesis?

We are looking for students regularly for both Master's thesis, Bachelor thesis, or small projects.

For more information contact below